Extreme environments or loading include space, vehicular accidents, explosions, impacts in sports, falls, thermal fatigue and sometimes even medical procedures. This area focuses on basic research in computational biomechanics to explore new numerical methods and investigations of injury mechanisms that may result from extreme loading conditions. We are exploring multiscale approaches that capture full body biodynamics extending to multiple length and time scales with much interest in how microstuctural aspects influence macroscopic behavior. There is an emphasis on the development and integration of coupled multiphysics including thermal, mechanical and electromagnetic effects into the solution of problems. Also of interest are numerical techniques for modeling the high strain rate deformation of soft tissue, bone fracture, fluid-structure interaction, fragmentation, shock physics and other transient dynamics. There is also an interest in optimizing parallelization and solver routines and algorithms that can help deal with the complex geometry required when modeling biological materials.